Skip to main content
Article thumbnail
Location of Repository

WH: Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS One 2012

By Jeremy Sokolove, Reuven Bromberg, Kevin D. Deane, Lauren J. Lahey, Lezlie A. Derber, Piyanka E. Ch, Jess D. Edison, William R. Gillil, Robert J. Tibshirani, Jill M. Norris, Michael Holers and William H. Robinson

Abstract

Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1 % of the world population and is a significant cause of worldwide disability. Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of immunologic events preceding the development of RA remains unclear. To characterize the evolution of the autoantibody response in the preclinical phase of RA, we used a novel multiplex autoantigen array to evaluate development of the anti-citrullinated protein antibodies (ACPA) and to determine if epitope spread correlates with rise in serum cytokines and imminent onset of clinical RA. To do so, we utilized a cohort of 81 patients with clinical RA for whom stored serum was available from 1–12 years prior to disease onset. We evaluated the accumulation of ACPA subtypes over time and correlated this accumulation with elevations in serum cytokines. We then used logistic regression to identify a profile of biomarkers which predicts the imminent onset of clinical RA (defined as within 2 years of testing). We observed a time-dependent expansion of ACPA specificity with the number of ACPA subtypes

Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.418.2807
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://robinsonlab.stanford.ed... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.