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Translational Polymorphism as an Important Source of Eukaryotic Proteins Variety

By Alex V. Kochetov, Nikolay A. Kolchanov and Akinori Sarai


Translation of most eukaryotic mRNAs is likely to be initiated by a linear scanning mechanism, although some other mechanisms are also possible [1]. According to the scanning model, 40S ribosomal subunits can either initiate translation at 5’-proximal AUG codon in a suboptimal context or miss it and initiate translation at downstream AUG(s) [1]. Eukaryotic mRNAs are often characterized by a suboptimal context of the predicte

Topics: eukaryotic mRNA, alternative AUGs, subcellular localization
Year: 2014
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