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Published on Web 12/13/2003 High Affinity, Paralog-Specific Recognition of the Mena EVH1 Domain by a Miniature Protein

By Dasantila Golemi-kotra, Rachel Mahaffy, Matthew J. Footer, Jennifer H. Holtzman, Thomas D. Pollard, Julie A. Theriot and Alanna Schepartz

Abstract

EVH1 domains are found within a large number of multidomain signaling proteins that regulate the dynamics of the actin cytoskeleton, including those where external stimuli regulate cellular motility, shape, and adhesion. 1 Examples include Drosophila Enabled (Ena) 2 and its mammalian counterparts Mena, 1a vasodilatorstimulated phosphoprotein (VASP), 3 Enabled/VASP-like protein (Evl), 1a and Wiskott-Aldrich syndrome protein (WASP). 4 EVH1 domains regulate actin filament dynamics through interactions with cytoskeleton-associated proteins including vinculin and zyxin, and are used by the ActA protein of Listeria monocytogenes during pathogenesis. 5 Like SH3 and WW domains, EVH1 domains recognize proline-rich sequences on target proteins6 that are folded into type II polyproline (PPII) helices. 7 In the case of L. monocytogenes

Year: 2003
OAI identifier: oai:CiteSeerX.psu:10.1.1.417.922
Provided by: CiteSeerX
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