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GASTROENTEROLOGY 2003;125:1750–1761 BASIC–ALIMENTARY TRACT A Murine Model of Chronic Inflammation–Induced Intestinal

By Fibrosis Down-regulated, Ian C. Lawrance, Feng Wu, André Z. A. Leite, Joseph Willis and Gail A. West


(ECM) changes underlying intestinal fibrosis, a frequent complication of inflammatory bowel disease, we developed a murine model of chronic colitis associated with intestinal fibrosis. Methods: Chronic inflammation was established by weekly intrarectal administration of trinitrobenzene sulfonic acid (TNBS). In 2 variations of the model an antisense oligonucleotide for nuclear factor � B (NF-�B) p65 was given prophylactically or therapeutically to block chronic inflammation–associated fibrosis. Colonic inflammation and fibrosis were determined by histology. Total collagen level was estimated by hydroxyproline quantification. Colonic expression of collagens (Col1a2, Col3a2), ECM remodeling genes (matrix metalloproteinase [MMP]-1,-3, and tissue inhibitor of matrix metalloproteinase [TIMP]-1), and inflammationmodulatin

Year: 2014
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