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THE IMPACT OF NEURAMINIDASE ON APOPTOSIS IN CULTURES OF BLOOD LYMPHOCYTES ISOLATED FROM RATS BEARING

By Morris Hepatoma, Kazimierz Gąsiorowski, Andrzej Steciwko and Jarosław Drobnik

Abstract

Abstract: Lymphocytes were obtained by heart-punction from rats bearing Morris hepatoma. In the short term, 18-hour cultures of these lymphocytes exhibited a significantly higher amount of apoptotic cells than lymphocyte cultures from the healthy, control animals. Neuraminidase, injected into the caudal vein of the rats with Morris hepatoma, caused a marked lowering in the amount of apoptotic blood-lymphocytes and an elevation of the amount of viable cells. The possible mechanism of neuraminidase preventing the apoptosis of blood-circulating lymphocytes in tumour hosts is discussed herein

Topics: Key Words, Morris Hepatoma, Rats, Lymphocyte Apoptosis, Neuraminidase
Year: 2004
OAI identifier: oai:CiteSeerX.psu:10.1.1.416.8794
Provided by: CiteSeerX
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