Location of Repository

X-ray diffraction and neutron scattering studies of amphiphile-lipid bilayer organization

By Pavol Balgavy, Daniela Uhrikova, Janka Karlovska, Martina Dubnic Kova, Norbert Kuc Erka, Ivan Lacko, Jozef C Izmarik, Karl Lohner, Gabor Degovics, Gert Rapp, Sergej Yaradaikin, Achmed Islamov and Valentin Gordeliy

Abstract

Abstract: The lipid bilayer thickness dL, the transbilayer distance of lipid phosphate groups dPP and the lipid surface area AL of fluid hydrated bilayers of lamellar phases of egg phosphatidylcholine or dipalmitoylphosphatidylcholine containing N-alkyl-N,N-dimethylamine N-oxides (CnNO), 1,4-butanediammonium-N,N≥-dialkyl-N,N,N≥,N≥-tetramethyl dibromides (GSn) or monohydrochlorides of [2-(alkyloxy)phenyl]-2-(1-piperidinyl)ethylesters of carbamic acid (CnA) were obtained by X-ray diffraction, and the bilayer thickness in extruded unilamellar dioleoylphosphatidylcholine vesicles containing C12NO was obtained by the neutron scattering. The values of dL, dPP and AL change linearly up to the 1:1 amphiphile:lipid molar ratio. The slopes of these dependencies increase for dL and dPP and decrease for AL with an increasing number of carbons n in the amphiphile long hydrocarbon substituent (18 ” n ” 8 for CnNO, 16 ” n ” 9 for GSn, 12 ” n ” 5 for CnA), while the opposite trends are observed for the short substituent (8 ” n ” 6 for CnNO, 9 ” n ” 7 for GSn, 5 ” n ” 3 for CnA). In case of long substituents, the effects on dL, dpp and AL are caused b

Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.416.5149
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://www.cmbl.org.pl/pdf/Vol... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.