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The effects of cerebrovascular and Alzheimer's disease on patterns of ventricular expansion rate derived from serial MRI. ISMRM

By C. Studholme, V. Cardenas, N. Schuff, M. Krishnan, H. Chui and M. W. Weiner


The expansion of the ventricular CSF-white matter boundary over time is of interest in short term serial MRI because of its high contrast and high rate of change. We examined magnitudes and patterns of ventricular expansion rate in cognitively normal elderly without (N=34) and with (N=18) lacunes, and in 18 Alzheimer’s patients without lacunes, using high-resolution tensor morphometry. Normal fusion visualization of the tensor field with respect to a reference ventricular surface revealed significant increases in expansion rate associated with both lacunes and Alzheimer’s disease. These findings highlight the importance of considering cerebrovascular and Alzheimer's disease as independent pathological processes. Objectives: To examine differences in the common patterns of ventricular expansion over time in three groups: cognitively normal subjects without lacunes, cognitively normal with lacunes and subjects diagnosed with Alzheimer’s disease

Year: 2002
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