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Formulation and Evaluation of Hydrogel Based Oral Controlled Release Tablets of Simvastatin

By Bushra Anjum, K. S. K. Rao Patnaik and C. V. S. Subrahmanyam

Abstract

Abstract- Hydrogel based tablets of Simvastatin was formulated using hydropropyl methyl cellulose(different grades), guar gum and carbopal-934-P with the aim to study of release kinetic, to attain a near zero order release and to increase the bioavalability upto 95%. In-vitro dissolution studies were carried out using USP type 2 dissolution test apparatus. The release of drug followed a typical Higuchian pattern. Hydrogel based tablets formulated employing hydropropyl methyl cellulose, guar gum and carbopal-934-P slow release of Simvastatin over period of 12 h and were found suitable for maintenance portion of oral controlled release tablets. Simvastatin release from these tablets were diffusion controlled and followed zero order kinetics after a lag time of 1h 1. The most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on Index Terms- Bioavalability, Carbopal-934-P, Formulation, Guar gum, Hydrogel, Hydropropyl methyl cellulose. Release kinetics study. D I

Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.414.9930
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