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Negative regulation of RNA polymerase III transcription by Maf1 protein

By Wodzimierz Baranowski and Magdalena Boguta


Hormonally dependent malignancies in women (endometrial tumors, ovarian and mammary glandcancers) areleading cause of death among women bearing malignant tumors.The steroid receptors (estrogen receptor — ER, and progesterone receptor — PR) status o�he tumor, apart fromhistological grade of neoplasm differentiation and clinical stage, seems to be an important and valuableprognostic marker as far as hormonal treatment efficacy and survival rate is concerned. The steroid receptors as transcriptionfactors regulatethe methylation pa�ern of genomic DNA and also the methylation of particular genes. The by-products od estrogen catabolic pathway (e.g. catecholestrogen derivatives) can induce hydrophobic DNA adducts formation leading to mutation(s) of important genes (suppressors and oncogenes). This review described the state of the art in the field of interplay between estrogen derivatives, estrogen receptor and genomic DNAmethylation (global methylation and metylation of particular genes), as well as pa�ern of DNA adducts in hormonal dependent tumors in women

Year: 2014
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