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on-line at: www.actabp.pl Trace elements and rat pouchitis

By Sławomira Drzymała-czyż, Tomasz Banasiewicz, Stanisław Walas, Tomasz Kościński, Ewa Wenska-chyży, Michał Drews and Jarosław Walkowiak

Abstract

The procedure of restorative proctocolectomy is associated with a complete removal of the colon and slight reduction of ileum length, which together can lead to systemic shortages of trace elements. Inflammatory changes in the pouch mucosa may also have some impact. However, there is no data on trace elements in pouchitis. Therefore, in the present study we aimed to assess the effect of acute pouchitis on the status of selected trace elements in rats. Restorative proctocolectomy with the construction of intestinal J-pouch was performed in twenty-four Wistar rats. Three weeks after the surgery, pouchitis was induced. Eight untreated rats created the control group. Liver concentrations of selected micronutrients (Zn, Cu, Co, Mn, Se) were measured in both groups six weeks later, using inductively coupled plasma mass spectrometry. Liver concentrations of trace elements did not differ between the study and the control groups. However, copper, cobalt and selenium concentrations [μg/g] were statistically lower (p<0.02, p<0.05 and p<0.04, respectively) in rats with severe pouchitis (n=9) as compared with rats with mild pouchitis (n=7

Topics: Key words, restorative proctocolectomy, pouchitis, trace elements
Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.414.8412
Provided by: CiteSeerX
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