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Uracil in DNA — friend or foe? New facts and hypothesis

By Ryszard Oliński, Marek Jurgowiak, Katarzyna Dorota Raczynska, G. Simpson, Adam Ciesiolka, Dominika Lew, Zofia Szweykowska-kulinska, John Brown and Artur Jarmolowski


Uracil may arise in DNA, in small quantities as a result of spontaneous cytosine deamination or/and misincorporation of dUMP during DNA replication. However, just recently uracil formation via enzymatic deamiantion of cytosine, has been found to underlies diversification of Ig genes and inhibition of retroviral infection. DNA deamination is the only known programme in mammalian development in which the coding capacity of the genome is changed by targeted modification of deoxycitidine. In this lecture: sources of the origin of uracil in DNA and the function of activation induced cytidine deaminase (AID) the enzyme which is responsible for cytidine deamination in Ig genes of B cell clones, will be reviewed. The role of uracil and above mentioned enzyme in Ig diversification process, which comprises somatic hypermutation and class switch recombination will also be discussed. Finally, possible involvement of aberrantly expressed AID and presence of uracil in DNA, in carcinogenesis will be discussed. L.C.2 Involvement of the nuclear capbinding protein complex in alternative splicing in Arabidopsis thalian

Year: 2014
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