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Copyright © American Society for Investigative Pathology Distinct Role of Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor on Tumor Growth and Angiogenesis

By Raffaella Giavazzi, Barbara Sennino, Daniela Coltrini, Angela Garofalo, Romina Dossi, Roberto Ronca, Maria Pia, Molinari Tosatti and Marco Presta


Tumors express more than a single angiogenic growth factor. To investigate the relative impact of fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) on tumor growth and neovascularization, we generated tumor cell transfectants differing for VEGF and/or FGF-2 expression. Human endometrial adenocarcinoma HEC-1-B-derived Tet-FGF-2 cells that express FGF-2 under the control of the tetracycline-responsive promoter (Tet-off system) were further transfected with a VEGF 121 antisense (AS-VEGF) cDNA. Next, Tet-FGF-2 and AS-VEGF/ Tet-FGF-2 cells were transplanted subcutaneously in nude mice that received tetracycline or not in the drinking water. Simultaneous expression of FGF-2 and VEGF in Tet-FGF-2 cells resulted in fast-growin

Year: 2014
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