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INFLUENCE OF MIDAZOLAM ON PHARMACOKINETICS OF VERAPAMIL IN RABBITS

By Pol J. Pharmacol, Daria Orszulak-michalak, Jacek Owczarek, Anna K. Wiktorowska-owczarek, D. Orszulak-michalak, J. Owczarek, A. K. Wiktorowska, Owczarek Pol and J. Pharmacol

Abstract

Calcium channel blockers can get involved in pharmacological interactions when used concomitantly with other drugs. Previous reports indicate a differential influence of various general anesthetics on verapamil pharmacokinetics. A tendency of a faster transfer of verapamil from the central compartment to the tissue compartment was found to be associated with a slower drug return from the tissue at the given verapamil doses during thiopental or propofol anesthesia. Thus, an increased storage of verapamil in tissue compartment and prolongation of the drug action may occur due to those interactions. The aim of the study was to investigate the influence of midazolam on the plasma concentrations and pharmacokinetic parameters of verapamil after intravenous bolus administration in rabbits during 2hofobservation. Verapamil and midazolam were administered intravenously at a dose of 0.2 mg/kg. Verapamil levels in plasma were determined by radioanalysis using [ ! H]verapamil. Levels of verapamil were determined in plasma a

Topics: Key words, verapamil, midazolam, pharmacokinetic parameters, rabbits correspondence D. Orszulak-Michalak, J. Owczarek, A.K. Wiktorowska-Owczarek
Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.413.9902
Provided by: CiteSeerX
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