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By D Roufogalis, Kevin Kw Wang and Biological Response A


clum Cellular signalling by Ca2+ occurs when the intracellular Ca2+ level rises from intracellular release or from influx from the extracellular space, The restoration of Ca2+ levels requires the subsequent removal of Ca2+ by sequestration into internal organelles or by extrusion across the plasma membrane, The Ca2+-ATPase in the plasma membrane is an important mechanism for the extrusion of Ca2+, In tllis first I}art of a two-l}art s{'ri{'s On t II{ ' str)lcture and ftrnction of the Ca2+ pump tile hasi( ' l)r()I)l'l.t il'! \ I)f 111l ' 1)lasma membrane calcium pump are reviewed, witjl l>arti('"I;tr l'mpll;tsis On it.s 1}11ysiological role, reaction pathway;llld bioe)lergeti~s, Next month regulatio)l of the Ca2+ pump and its molecular structure will be discussed

Year: 2014
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