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Location of Repository Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

By Alba Naudí, Mariona Jové, Victòria Ayala, Rosanna Cabré, Manuel Portero-otín and Reinald Pamplona


Abstract: Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties

Topics: advanced glycation endproducts, advanced lipoxidation endproducts, age-associated diseases
Year: 2013
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