theory for a long time that provided scientific thinking in fields of biology and medicine  and also in recent western medicine, especially in cardiovascular system [2,3]. The Yin-Yang sign was also described in radiology, mainly a configurative description of the partially thrombosed artery aneurysm [4-6]. Yang represents hot or energetic while Yin stands for cold or withdrawn. Greer’s description of Daruma’s clinical manifestations was the typical Yin-Yang illustration in terms of its functional orientation . In this issue of our Journal, professor Shih, et al. further applied Yin-Yang Tai-Chi Symbol as a basic principle for nuclear medicine diagnosis . The Symbol is well known as a representative of opposites, harmonization, and balance. We can easily recognize it in the Chinese community. However, it appears no one has linked it with nuclear imaging interpretation or maybe there has been someone who realized this relationship but has not recorded it. Professor Shih, who lives in the western country, noticed it, carefully studied and made a record . This linkage may provide a clue for the interplay between modern nuclear medicine (personalized molecular imaging) and scientific Chinese medicine (evidence based approach) in dealing with concurrent treatment (personalized molecular medicine) of current diseases [9,10]. In clinical nuclear medicine practice, lesions seen on nuclear imaging are often higher or lower in radioactivity
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