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Mortality Associated with Implantation and Management of Intrathecal Opioid Drug Infusion Systems to Treat

By Noncancer Pain


Background: In 2006, the authors observed a cluster of three deaths, which circumstances suggested were opioid-related, within 1 day after placement of intrathecal opioid pumps for noncancer pain. Further investigation suggested that mortality among such patients was higher than previously appreciated. The authors performed investigations to quantify that mortality and compare the results to control populations, including spinal cord stimulation and low back surgery. Methods: After analyzing nine index cases–three sentinel cases and six identified by a prospective strategy–the authors used epidemiological methods to investigate whether mortality rates reflected patient- or therapy-related differences. Mortality This article is featured in “This Month in Anesthesiology.” Please see this issue of ANESTHESIOLOGY, page 9A. This article is accompanied by an Editorial View. Please see

Topics: Safety Director, Neuromodulation Regulatory Affairs, ‡ Director
Year: 2014
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