Other than malignancy, benign processes, such as infection, inflammation and granulomatous diseases, may also show enhanced glycolysis when stimulated and result in increased 18 F-fluoro-2-deoxy-D-glucose (FDG) uptake. In this case report, we present a patient of lung cancer with an unusual pattern of FDG uptake on the rim of the gallbladder in FDG positron emission tomography (PET) for staging his lung malignancy. The findings in subsequent ultrasonography signified possible cholecystitis for the patient. Although lacking clinical symptom with our patient, it is very likely that asymptomatic cholecystitis have occurred and resulted in the increased FDG uptake of his gallbladder wall
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