Malignant pleural effusion is the most common complicated by primary pulmonary carcinoma, but is seldom in patients with esophageal carcinoma. We present a patient with a 5-6 month history of gradual dysphagia of solid foods and gurgling with liquids whose computed tomography (CT) images of the chest showed left pleural effusion. 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging revealed increased FDG uptake in the distal end of esophagus and in the posterior left chest wall. An aspiration of the left-side pleural effusion was done; cytologic examination of the aspirated effusion was positive for malignancy, consistent with adenocarcinoma of esophagus. The clinical roles of PET imaging in patients with malignant pleural effusion are discussed. Key words: malignant pleural effusion, esophageal carcinoma, 18 F-FDG-PET Ann Nucl Med Sci 2006;19:45-49 Malignant pleural effusion is frequently complicated by lung and breast cancer, but is rare in patients with esophagus cancer [1,2]. In recent years, there have been reports tha
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