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Possible West Nile Virus Transmission to an Infant Through

By Breast-feeding Michigan


infection in a woman, who received a blood product later found with evidence of WNV, and in her child, who was exposed to breast milk later found to be WNV positive by TaqMan ® (1). This report updates the findings of this investigation. On September 2, 2002, a woman aged 40 years delivered a healthy infant but required transfusion of two units of packed red blood cells (RBC) for anemia. The patient received the first unit 6 hours after delivery and the second on the following day. The second transfusion was derived from the same donation as a unit of platelets given to a liver transplant recipient who developed confirmed West Nile meningoencephalitis (WNME); the blood donor’s original tubing segment from this common donation was WNV positive by TaqMan ® (1). Approximately 2 hours after delivery, the patient developed a migraine headache, photophobia, and anomia. The patient had a history of migraine headaches. When she was discharged 2 days after delivery, her headache was resolving. Eight days later, the patient developed a severe, persistent headache that differed qualitatively from her migraine headache. Twelve days after delivery, the patient reported developing fever, and 3 days later she was admitted with a fever of 102.8º F (39.3º C) and peripheral white blood count (WBC) of 2,900/mm 3 (normal: 3,900–11,100/mm 3). Laboratory examination of the cerebrospinal fluid (CSF) revealed a WBC count of 134/mm 3 (normal: <10/mm 3) with 10% neutrophils, a protein concentration of 57 mg/dL (normal: 12–60 mg/dL), and a glucose concentration of 57 mg/dL (normal: 40–70 mg/dL). Computerized tomography of the head was normal. A CSF sample tested at MDCH was positive for WNV-specific IgM. The woman recovered from WNME and was discharged from the hospital

Year: 2014
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