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Local delivery of fibrinolysis enhancing agents

By Jeffrey A. Hubbell, Jennifer L. Hill-West and Randall C. Dunn


A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolyic agent, preferably urokinase, or tPA. In the most preferred embodiment, the matrix is extremely thin and is polymerized in situ to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase or tPA is effective in preventing surgical adhesions.Board of Regents, University of Texas Syste

Topics: A61K9/0024, A61K9/0014, A61K9/1635, A61K9/1647, A61K38/482, A61K38/49, A61K38/58, A61K47/32, A61L24/0031, A61L24/0042, A61L24/046, A61L27/34, A61L27/52, A61L29/085, A61L31/145, A61L31/148, A61L31/16, A61K2035/128, A61L2300/254, A61L2300/424, A61L2300/602, A61L2300/604, C08F290/00, C08F290/06, C08F291/00, C09D153/00, C12N5/0012, C12N5/0677, C12N11/04, C12Y304/21, C12Y304/21073, C12N2533/30, C12N2533/32, C12N2533/40, C12N2533/74, 424/484, 424/485, 424/486, 424/487, 424/488, 514/13.6, 514/14.2, 514/14.6
Publisher: United States Patent and Trademark Office
Year: 1993
DOI identifier: 10.26153/tsw/3692
OAI identifier:
Provided by: UT Digital Repository
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