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Anticancer activity evaluation of kuanoniamines a and c isolated from the marine sponge oceanapia sagittaria, collected from the gulf of thailand

By Anake Kijjoa, Rawiwan Wattanadilok, Nair Campos, Maria São, José Nascimento, Madalena Pinto and Werner Herz


Abstract: The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells. Mar. Drugs 2007, 5

Topics: Oceanapia sagittaria, kuanoniamines A and C, anticancer activity, cell cycle progression, apoptosis, anti-proliferation of human lymphocytes
Year: 2013
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