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Anticancer activity evaluation of kuanoniamines a and c isolated from the marine sponge oceanapia sagittaria, collected from the gulf of thailand

By Anake Kijjoa, Rawiwan Wattanadilok, Nair Campos, Maria São, José Nascimento, Madalena Pinto and Werner Herz

Abstract

Abstract: The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells. Mar. Drugs 2007, 5

Topics: Oceanapia sagittaria, kuanoniamines A and C, anticancer activity, cell cycle progression, apoptosis, anti-proliferation of human lymphocytes
Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.394.2687
Provided by: CiteSeerX
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