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knowlesi Infection

By Nimol Khim, Sovannaroth Siv, Saorin Kim, Tara Mueller, Erna Fleischmann, Balbir Singh, Paul Cliff, Simon Divis, Nicolas Steenkeste, Socheat Duong, Frederic Ariey and Didier Ménard


Two cases of Plasmodium knowlesi infection were identified in humans in Cambodia by 3 molecular detection assays and sequencing. This finding confirms the widespread distribution of P. knowlesi malaria in humans in Southeast Asia. Further wide-scale studies are required to assess the public health relevance of this zoonotic malaria parasite. In Cambodia, malaria ranks among the leading causes of illness and death. Mostly affecting the ≈3 million persons (23 % of Cambodia’s population) who live near forested areas, malaria remains an occupational disease in specific high-risk groups, such as forestry workers and migrant populations who have come into forested areas. However, for the past decade, the number of reported malaria cases has generally decreased but in a sawtooth pattern of periodic increases (1). Four of the 5 Plasmodium species known to cause malaria in humans have already been described in Cambodia (2,3). P. falciparum remains the most frequent cause of malaria (83,777 cases in 2009, prevalence of 70%) (1). However, distributions of Plasmodium species are changing, with a particularly substantial increase of P. vivax malaria cases, from 4,105 (8%) cases in 2000 to 6,250 (25%) in 2009. In several areas of low transmission, the proportion of P. vivax infections has increased up t

Year: 2013
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