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Colonic adenoma with squamous metaplasia

By MD Liron Pantanowitz

Abstract

Squamous metaplasia arising within colon adenomas is a rare occurrence, with a 0.4% incidence noted predominantly in elderly males. A case of squamous metaplasia arising in a tubulovillous adenoma of the cecum, associated with adenocarcinoma, is described. Squamous metaplasia was immunoreactive for beta-catenin, but negative for cytokeratin 20, CDX2, p63, estrogen receptor, progesterone receptor, p16, and human papilloma virus. Squamous differentiation may serve as a precursor lesion for squamous neoplasia of the colorectum

Topics: Pathology
Publisher: Scholarly Commons @ Baystate Health
Year: 2009
OAI identifier: oai:scholarlycommons.libraryinfo.bhs.org:all_works-1614
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