This copy is for your personal, non-commercial use only. If you wish to distribute this article to others, you can order high-quality copies for your colleagues, clients, or customers by clicking here. Permission to republish or repurpose articles or portions of articles can be obtained by following the guidelines here. The following resources related to this article are available online at www.sciencemag.org (this information is current as of February 22, 2010): Updated information and services, including high-resolution figures, can be found in the online version of this article at
To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.