P-16 Anticancer Activity of Selected Alpha-Cyanostilbenes

Abstract

Cancer continues to be one of the leading causes of death in the US. Resveratrol, a naturally occurring compound, has shown promising anticancer properties in many studies. Through a reflux process, we were able to combine different phenylacetonitriles and benzaldehydes and thus created resveratrol analogs that have bicyclic structures but different functional groups coming off the carbon skeleton. We synthesized and analyzed nine of these analogs, known as alpha-cyanostilbenes. We then tested different concentrations of the alpha-cyanostilbenes on glioblastoma cells in order to determine effective dose after a 24-hour incubation. Analysis of this data is still under way

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