Phase I Study of MEDI-534 of a Live, Attenuated Intranasal Vaccine Against Respiratory Syncytial Virus and Parainfluenza-3 Virus in Seropositive Children

Gomez, Margarita; Mufson, Maurice A.; Dubovsky, Filip; Knightly, Conor; Zeng, Wen; Losonsky, Genevieve

oai:mds.marshall.edu:int_med-1011

Phase I Study of MEDI-534 of a Live, Attenuated Intranasal Vaccine Against Respiratory Syncytial Virus and Parainfluenza-3 Virus in Seropositive Children

Authors: Margarita Gomez
Maurice A. Mufson
Filip Dubovsky
Conor Knightly
Wen Zeng
Genevieve Losonsky
Publication date: July 1, 2007
Publisher: Marshall Digital Scholar

Abstract

A live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine was evaluated in healthy respiratory syncytial virus/parainfluenza virus type 3 seropositive children aged 1 to 9 years. Three cohorts of 40 children were randomized 1:1 to receive 104, 105 or 106 median tissue culture infectious dose50 MEDI-534 vaccine of placebo. The vaccine\u27s safety profile was similar to placebo, no viral shedding was detected, and the vaccine was minimally immunogenic

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oai:mds.marshall.edu:int_med-1011Last time updated on 10/29/2019View original full text link

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