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sVEGFR-2 and its Role in Lymphangiogenesis Modulation

By Jayakrishna Ambati and Romulo J. Albuquerque

Abstract

Disclosed herein are nucleic acid molecules comprising a nucleotide sequence of sVEGF-2, proteins encoded by those sequences and antibodies that bind to the protein. Also disclosed are methods for inhibiting or enhancing expression or activity of sVEGFR-2 and methods for inhibiting graft rejection, particularly cornea graph rejection. Also described are methods for inhibiting lymphangiogenesis and lymphatic endothelial cell proliferation by administering an effective amount of sVEGFR-2 and methods for treating lymphedema by inhibiting the activity of sVEGFR-2

Topics: sVEGFR-2, lymphangiogenesis modulation, role, Ophthalmology
Publisher: UKnowledge
Year: 2014
OAI identifier: oai:uknowledge.uky.edu:ophthalmology_patents-1008

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