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Editorial Colony variability under the spotlight in animal models of arthritis

By John H Robinson

Abstract

A recent article by Farkas and colleagues, published in Arthritis Research & Therapy, is from the laboratory of Dr Tibor Glant and his research team in Chicago, who have investigated in considerable depth the immunopathology of experimental arthritis induced by the major cartilage component proteoglycan aggrecan in an animal model that mimics many features of human rheumatoid arthritis and ankylosing spondylitis. This present report takes our understanding a significant step forward by questioning whether genetic drift in distinct colonies of the same inbred strains of mice has an impact on the parity between data published by different laboratories. In the previous issue of Arthritis Research & Therapy, Farkas and colleagues [1] compare a large number of colonies of the widely used BALB/c inbred mouse strain; the authors communicat

Year: 2009
OAI identifier: oai:CiteSeerX.psu:10.1.1.358.9460
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