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Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes

By Joline W. J. Beulens, Daphne L. Van Der A, Diederick E. Grobbee, Ivonne Sluijs and Yvonne T. Van Der Schouw


OBJECTIVE — To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS — We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20–70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS — During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P � 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95 % CI 0.66–0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P � 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87–1.00) for each 10-�g increment in the multivariate model. CONCLUSIONS — This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes. Diabetes Care 33:1699–1705, 201

Year: 2013
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