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There is a slight increase in incident diabetes risk with the use of statins, but benefits likely outweigh any adverse effects in those with moderate-to-high cardiovascular risk

By Lokpal Bhatia and Christopher D. Byrne

Abstract

Statins are one of the most widely used drug classes, with approximately 50 million prescriptions dispensed in England alone in 2008. Their efficacy and safety in significantly reducing cardiovascular events in moderate-to-high-risk patients has been well documented, both in primary and secondary prevention. 1 Commonly reported side-effects include muscle aches and increases in liver enzymes, but, in general, statins are well tolerated with a low incidence of side-effects. However, the recent collaborative meta-analysis of 13 major placebo-controlled statin trials by Sattar and colleagues reports a 9% increased risk for incident diabetes over 4 years (OR 1.09; 95% CI 1.02-1-17) in patients randomised to statins compared to those assigned to placebo. Heterogeneity between trials was low (I 2=11%), suggesting that this risk appears to be a true class effect, despite known differences in lipophilicity and metabolic clearance pathways between individual statin drugs<br/

Topics: QR180, RB, RM
Year: 2010
OAI identifier: oai:eprints.soton.ac.uk:176479
Provided by: e-Prints Soton

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Citations

  1. Effi cacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. doi
  2. High-dose atorvastatin associated with worse glycaemic control: a PROVE-IT TIMI 22 substudy.
  3. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. doi
  4. Statins: benefi cial or adverse for glucose metabolism. doi

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