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Understanding protein-protein . . .

By Ariel Jaimovich

Abstract

All living organisms consist of living cells and share basic cellular mechanisms. Amazingly, all those cells, whether from a bacterium or a human being, although different in their structure and complexity, comprise the same building blocks of macro molecules: DNA, RNA, and proteins. Proteins play major roles in all cellular processes: they create signaling cascades, regulate almost every process in the cell, act as selective porters on the cell membrane, accelerate chemical reactions, and many more. In most of these tasks, proteins work in concert, by creating complexes of varying sizes, modifying one another and transporting other proteins. These interactions vary in many aspects: they might take place under specific conditions, have different biophysical properties, different functional roles, etc. Identifying and characterizing the full repertoire of interacting protein pairs are of crucial importance for understanding the functionality of a living cell. In the last decade, development of new technologies allowed large-scale measurements of interaction networks. In turn, many studies used the results of such assays t

Year: 2010
OAI identifier: oai:CiteSeerX.psu:10.1.1.352.9658
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