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First Description of Azole-Resistant Aspergillus fumigatus Due to TR 46 /Y121F/T289A Mutation in France

By Rose-Anne Lavergne, Florent Morio, Loïc Favennec, Stéphane Dominique, Jacques Meis, Gilles Gargala, Paul Verweij and Patrice Le Pape

Abstract

International audienceAzole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance

Topics: [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Publisher: 'American Society for Microbiology'
Year: 2015
DOI identifier: 10.1128/AAC.00127-15
OAI identifier: oai:HAL:hal-02317942v1

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