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www.mdpi.com/journal/ijms Lipidosterolic Extract of Serenoa Repens Modulates the Expression of Inflammation Related-Genes in Benign Prostatic

By Hyperplasia Epithelial, Stromal Cells, Nanor Sirab, Grégoire Robert, Virginie Fasolo, Aurélien Descazeaud, Francis Vacherot and Stéphane Terry

Abstract

Abstract: Despite the high prevalence of histological Benign Prostatic Hypeplasia (BPH) in elderly men, little is known regarding the molecular mechanisms and networks underlying the development and progression of the disease. Here, we explored the effects of a phytotherapeutic agent, Lipidosterolic extract of the dwarf palm plant Serenoa repens (LSESr), on the mRNA gene expression profiles of two representative models of BPH, BPH1 cell line and primary stromal cells derived from BPH. Treatment of these cells with LSESr significantly altered gene expression patterns as assessed by comparative gene expression profiling on gene chip arrays. The expression changes were manifested three hours following in vitro administration of LSESr, suggesting a rapid action for this compound. Among the genes most consistently affected by LSESr treatment, we found numerous genes that were categorized as part of proliferative, apoptotic, and inflammatoryInt. J. Mol. Sci. 2013, 14 1430

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.352.8490
Provided by: CiteSeerX
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