mortality and acute kidney injury in critically ill patients Zarychanski R, Abou-Setta AM, Turgeon AF, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA. 2013;309:678-88. Clinical impact ratings: E ★★★★★★ ✩ c ★★★★★★★ Question In critically ill patients receiving acute volume resuscitation, what are the efficacy and safety of hydroxyethyl starch (HES) solutions? Review scope Included studies compared HES with other IV fluids (crystalloid solutions, albumin, or gelatins) for acute resuscitation in critically ill patients ≥ 18 years of age in intensive care units or emergency departments. Outcomes included mortality; use of renal replacement therapy (RRT); and risk for renal dysfunction, injury, and failure based on RIFLE criteria. Review method
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