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Antigen-Specific B Cells Reactivate an Effective Cytotoxic T Cell Response against Phagocytosed Salmonella through Cross-Presentation

By Jelle De Wit, Yuri Souwer, Tineke Jorritsma, Hanny Klaasse Bos, Anja Ten Brinke, Jacques Neefjes and S. Marieke Van Ham

Abstract

Background: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8 + T cell response. Dendritic cells (DCs) are considered to orchestrate the cytotoxic CD8 + T cell response via cross-presentation of bacterial antigens onto MHC class I molecules. Cross-presentation of Salmonella by DCs however, is accompanied by the induction of apoptosis in the DCs. Besides antibody production, B cells are required to clear Salmonella infection for other unknown reasons. Methodology/Principal Findings: Here we show that Salmonella-specific B cells that phagocytose Salmonella upon BCRligation reactivate human memory CD8 + T cells via cross-presentation yielding a Salmonella-specific cytotoxic T cell response. The reactivation of CD8 + T cells is dependent on CD4 + T cell help. Unlike the DCs, B cell-mediated crosspresentation of Salmonella does not coincide with apoptosis. Conclusions/Significance: B cells form a new player in the activation of the cytotoxic effector arm of the immune respons

Year: 2010
OAI identifier: oai:CiteSeerX.psu:10.1.1.352.1127
Provided by: CiteSeerX
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