Abstract In the course of chronic kidney disease (CKD) the intracellular erythrocyte calcium (Cai 2+) level increases along with the progression of the disease. The decreased activity of Ca 2+-Mg 2+-dependent ATP-ase (PMCA) and its endogenous modulators calmodulin (CALM), calpain (CANP), and calpastatin (CAST) are all responsible for disturbed calcium metabolism. The aim of the study was to analyze the activity of PMCA, CALM, and the CANP-CAST system in the red blood cells (RBCs) of hemodialyzed (HD) children and to estimate the impact of a single HD session on the aforementioned disturbances. Eighteen patients on maintenance HD and 30 healthy subjects wer
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