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Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice

By María Celeste Bigliani, Ezequiel Grondona, María Paula Zunino and A. A. Ponce

Abstract

Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentin

Topics: CECROPIA PACHYSTACHYA, LARREA DIVARICATA, MICE, PLANTS, PLUS-MAZE, Bioquímica y Biología Molecular, Ciencias Biológicas, CIENCIAS NATURALES Y EXACTAS
Publisher: 'SAGE Publications'
Year: 2010
DOI identifier: 10.1177/0960327109358613
OAI identifier: oai:ri.conicet.gov.ar:11336/85708
Provided by: CONICET Digital
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