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The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Leptin Production and Release in the Dually in Vitro

By Perfused Human Placenta, Knud Linnemann, Antoine Malek, Ruth Sager, Werner F. Blum, Henning Schneider and Christoph Fusch


There is clear evidence that the placenta produces leptin. However, it is still unclear to what extent leptin is released into the maternal and the fetal circulation. The aim of our study was to determine placental leptin release rates into these 2 compartments. In 10 term placentas, using dual in vitro perfusion of an isolated cotyledon, concentrations of leptin, hCG, and human placental lactogen (hPL) were determined in perfusates and in the tissue before and after perfusion. With perfusions lasting 270–840 min, total leptin production was 225 pg/g�min [median; interquartile range (IQR), 76–334 pg/g�min]. The release into the fetal circulation was very low (median, 2.5; IQR, 1.1–5.9 pg/g�min) compared with the release into the maternal circulation (median, 203; IQR, 79–373 pg/g�min) corresponding to 1.6% and 98.4 % of net release. Only 0.05 % of hPL and hCG were release

Year: 2000
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