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The expression of aromatase in gonadotropes is regulated by estradiol and gonadotropin-releasing hormone in a manner that differs from the regulation of luteinizing hormone. Endocrinology 147, 4234– 4244. Gazzaley

By Guillaume Galmiche, Nicolas Richard, Sophie Corvaisier and Marie-laure Kottler


THE REGULATION OF the anterior pituitary is achieved by the cell-specific and combined actions of central, peripheral, and local factors. It is established that estrogens are involved in the modulation of the hypothalamic-pituitary-gonadal axis. However, it is difficult to delineate the overall contribution of each site of action, particularly at the level of the pituitary gland. The biosynthesis of estrogens from androgens is catalyzed by the aromatase complex, which consists of cytochrome P450 aromatase (P450arom) and a flavoprotein, reduced nicotinamide adenine dinucleotide phosphate-cytochrome P450 reductase (1). The P450arom is encoded by a single copy gene, cyp19, composed of nine coding exons (exons II–X). The cyp19 gene expression is regulated by multiple tissue-specific promoters producing alternate 5�-untranslated exons I that are then spliced onto a common 3�-splice acceptor site in the exon II upstream of the translation start site (2). However, all transcripts contain a

Topics: Abbreviations, CREB, cAMP response element-binding protein, DPN, diarylpropionitrile, E2, estradiol, ER, estrogen receptor, �ERKO, ER � knockout, GnRH-R, GnRH receptor, OVX, ovariectomized, P450arom, cytochrome P450 aromatase, pCREB, phospho-CREB, PPT
Year: 2006
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