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Printed in U.S.A. Copyright © 2000 by The Endocrine Society Female Fertility Is Reduced in Mice Lacking Ca 2 � / Calmodulin-Dependent Protein Kinase IV*

By Joy Y. Wu, Ignacio J. Gonzalez-robayna, Joanne S. Richards and Anthony R. Means


Ca 2 � /calmodulin-dependent protein kinase IV (CaMKIV) is a serine/threonine protein kinase with limited tissue distribution. CaMKIV is highly expressed in the testis, where it is found in transcriptionally inactive elongating spermatids. We have recently generated mice deficient in CaMKIV. In the absence of CaMKIV, the exchange of sperm nuclear basic proteins in male spermatids is impaired, resulting in male infertility secondary to defective spermiogenesis. The involvement of CaMKIV in female fertility has not been addressed. Here we report that female fertility is markedly reduced CA2 � /CALMODULIN-DEPENDENT protein kinase IV (CaMKIV) is a multifunctional serine/threonine protein kinase expressed in a limited number of tissues including brain, thymus, bone marrow, and testis. It is encoded by the Camk4 gene, which also expresses calspermin, an abundan

Year: 2013
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