Article thumbnail

Endotheli n Stimulates M itogen-Activated Protein Kinase Activity in Mesangial Cells Through ETA1

By Yizheng Wang and Michael J. Dunn

Abstract

Accumulating evidence suggests that endothelin (ET) contributes to the pathophysiology of such disorders as acute renal failure, cyclosporine-mediated renal and vascular toxicity, and perhaps even glomerular inflammation. The postreceptor signaling pathways that mediate the actions of ET in these pathophysiologic conditions may include activation of kinase cascades. Thus, the effects of ET isopeptides on p42 and p44 mitogen-activated protein (MAP) kinase activity in rat glomerular mesangial cells were exammed. ET-1 activated both p42 and p44 MAP kinases with similar dose responses and different kinetics. The threshold for kinase activation was 10 M ET-1. ET-1 stimulated p42 and p44 MAP kinases with similar rapi

Topics: E ndothehins (ET) are a family of 2
Year: 1994
OAI identifier: oai:CiteSeerX.psu:10.1.1.326.9227
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://jasn.asnjournals.org/co... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.