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Endotheli n Stimulates M itogen-Activated Protein Kinase Activity in Mesangial Cells Through ETA1

By Yizheng Wang and Michael J. Dunn


Accumulating evidence suggests that endothelin (ET) contributes to the pathophysiology of such disorders as acute renal failure, cyclosporine-mediated renal and vascular toxicity, and perhaps even glomerular inflammation. The postreceptor signaling pathways that mediate the actions of ET in these pathophysiologic conditions may include activation of kinase cascades. Thus, the effects of ET isopeptides on p42 and p44 mitogen-activated protein (MAP) kinase activity in rat glomerular mesangial cells were exammed. ET-1 activated both p42 and p44 MAP kinases with similar dose responses and different kinetics. The threshold for kinase activation was 10 M ET-1. ET-1 stimulated p42 and p44 MAP kinases with similar rapi

Topics: E ndothehins (ET) are a family of 2
Year: 1994
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