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By Irene Orlow, Ming-lan Lu, Marija Drobnjak Maria Dudas, Elizabeth Charytonowicz Guido and Dalbagni Carlos Cordon-cardo


Background: We sought to identify and characterize potential alterations in E2F-1, a transcription factor that binds to the retinoblastoma protein (pRB), in bladder neoplasms and to elucidate a possible role for E2F-1 as an oncogene or a tumor suppressor gene. Methods: Tumor samples from 133 evaluable patients with bladder cancer were analyzed for E2F-1 gene mutations by use of polymerase chain reaction–singlestrand conformational polymorphism (PCR–SSCP) analysis and DNA sequencing. In addition, tumors were studied for E2F-1 and pRB protein expressio

Year: 2013
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