Many parasitologists are betting heavily on proteomic studies to explain biochemical host–parasite interactions and, thus, to contribute to disease control. However, many ‘parasitoproteomic ’ studies are performed with powerful techniques but without a conceptual approach to determine whether the host genomic responses during a parasite infection represent a nonspecific response that might be induced by any parasite or any other stress. In this article, a new conceptual approach, based on evolutionary concepts of immune responses of a host to a parasite, is suggested for parasitologists to study the host proteome reaction after parasite invasion. Also, this new conceptual approach can be used to study other host– parasite interactions such as behavioral manipulation. The study of host–parasite interaction
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