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recognition of premature stop codon. Translation in metazoan cell nuclei has been reported (Iborra et al., 2001) but recent evidences suggested that this should be taken with caution (Bohnsack et al., 2002; Dahlberg et al., 2003; Nathanson et al., 2003). Therefore, it is currently believed that NMD occurs during a pioneering round of translation once the newly synthesized mRNAs reach the cytoplasm after export through the nuclear pore complex, thus, being closely associated with the nucleus (Ishigaki et al., 2001). Newly exported mRNA substrates for NMD are recognized through their association with the nuclear cap-binding complex that transits with them from the nucleus to the cytoplasm (Visa et al., 1996). They are also punctuated with exon junction complexes that mark the location of excised introns, thus, playing a

Year: 2004
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