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By Xiaowei Ma, Simonetta Bacci, Wojciech Mlynarski, Lucia Gottardo, Teresa Soccio, Elisabetta Iori, Robert A. Lager, Adhir R. Shroff, Ernest V. Gervino, Richard W, Michael T. Johnstone, Nada A. Abumrad, Angelo Avogaro, Vincenzo Trischitta and Alessandro Doria


Copyright © 2004 Oxford University PressHMG-2004W-00300-Revised 2 CD36 is a class B scavenger receptor recognizing a variety of ligands including long-chain fatty acids and modified LDL. We investigated whether genetic variability at this locus is a determinant of free fatty acids (FFA) plasma levels and risk of coronary artery disease in Caucasians. Typing of 21 polymorphic markers evenly spanning the CD36 gene revealed two linkage disequilibrium blocks that could be tagged by five polymorphisms (-33137A>G,-31118G>A, 25444G>A, 27645del>ins, and 30294G>C). In 585 non-diabetic individuals of Caucasian origin, the 30294G>C polymorphism was significantly associated with FFA levels (p=0.02) – an effect that was especially visible among men (p=0.009). A similar association was observed in this gender at –33137 (p=0.008) and-31118 (p=0.028)

Topics: Joslin Diabetes Center
Year: 2004
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