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REVIEW Demyelinating and Neurologic Events Reported in Association With Tumor Necrosis Factor � Antagonism By What Mechanisms Could Tumor Necrosis Factor � Antagonists Improve Rheumatoid Arthritis but Exacerbate Multiple Sclerosis?

By William H. Robinson, Mark C. Genovese and Larry W. Morel


Tumor necrosis factor � (TNF�) inhibition is the most significant advancement in the treatment of rheumatoid arthritis (RA) since the adoption of methotrexate in the 1980s (1,2). As TNF � antagonists hav

Year: 2013
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