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RAPID COMMUNICATION Clonal, Nonconstitutional Rearrangements of the MLL Gene in Infant Twins With Acute Lymphoblastic Leukemia: In Utero Chromosome Rearrangement of 1 lq23

By Heidi J. Gill Super, Paul G. Rothberg, Hirofumi Kobayashi, Arnold I. Freeman, Manuel Diaz and Janet D. Rowley


Rearrangements of chromosome band q23 1 1 are common in infant leukemias, comprising more than 70 % of the observed chromosome abnormalities in children less than 1 year of age. The MLL gene, which is located at the 1 1 q23 breakpoint in infant, childhood, and adult acute leukemias, has been cloned and has homology to the Drosophila trithorax gene. The breakpoints in MLL are restricted to an 8.3-kilobase pair (kb) region of the gene that is involved in translocations with as many as 29 other chromosomal regions in a number of phenotypically distinct acute leukemias. We have detected an identical, clonal, nonconstitutional rearrangement of the MLL gene in peripheral blood R ECURRING CHROMOSOME rearrangements are a common feature of most human hematologic malignancies

Year: 2013
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