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Silymarin Protects Against Liver Damage in BALB/c Mice Exposed to Fumonisin B1 Despite Increasing Accumulation of

By Free Sphingoid Bases, Quanren He, Jiyoung Kim and Raghubir P. Sharma

Abstract

Fumonisin B 1 (FB 1) is a mycotoxin produced by Fusarium verticillioides found on corn and corn-based foods. It causes equine leukoencephalomalacia, porcine pulmonary edema, and liver and kidney damage in most animal species. Fumonisin B 1 perturbs sphingolipid metabolism by inhibiting ceramide synthase activity, leading to the production of cell signaling factors including tumor necrosis factor a (TNF-a). The signal pathways of TNF-a are important factors in the pathogenesis of FB 1 hepatotoxicity. In the present study, female BALB/c mice were treated daily with 750 mg/kg silymarin by gavage and 2.25 mg/kg FB1 subcutaneously for 3 days. Then, 1 day after the last FB 1 injection, the mice were euthanized and blood and tissues were sampled for analyses. Silymarin significantly diminished FB1-induced elevation of plasma alanine aminotransferase and aspartate aminotransferase activities and the number of apoptotic hepatocytes, while it augmented hepatocyt

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.321.7315
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