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Current Signal Transduction Therapy, 2006, 1, 91-100 91 Signal Transduction Therapy of Diabetic Vascular Complication

By Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Yumiko Yoshida, Katsuhiko Takenaka, Yuko Jinnouchi and Tsutomu Imaizumi


Abstract: Diabetic vascular complication is a leading cause of end-stage renal failure, acquired blindness, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. There is a growing body of evidence to conclude that intensive control of plasma glucose and blood pressure is crucial for effectively reducing diabetic vascular complication. So far, various molecular mechanisms have been proposed to play a role in the development and progression of diabetic vascular complication. In this paper, we review potential therapeutic strategies for the prevention of diabetic vascular complication, especially focusing on the signal transduction pathways activated under diabetes. Key Words: Advanced glycation end products, diabetic vascular complication, oxidative stress, renin-angiotensin system

Year: 2013
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